Given the limited accommodation options and the nature of Mount Vernon, the best area to stay is generally along or just off US-395, the main highway passing through the town.This central strip provides access to the few local businesses and services available. You'll find the main street, which is part of US-395, features the town's small grocery store, a couple of eateries, and the gas station. It's a very small, rural community, and the available lodging tends to be concentrated in this central area for convenience.For solo travellers or couples passing through, staying in Mount Vernon offers a practical stopover. It's a good base for exploring the John Day Fossil Beds National Monument, with the Sheep Rock Unit being a relatively short drive away.